Thymosin 𝛃-4 and BPC-157
BPC-157 and TB4 are two powerful peptides that have been shown to provide pain management, wound healing, anti-inflammatory properties, and much more. These two peptides have been gaining increasing attention from the wellness community due to their purported benefits that can help treat problematic stomach conditions while also helping to turbocharge the body’s natural healing mechanisms. While they do have some key similarities, each of these peptides has its own unique benefits depending on your unique needs and lifestyle. All of this is just the tip of the iceberg when it comes to these two miracle peptides – so let’s dive right in!
What is Thymosin 𝛃-4?
Thymosin Beta-4 (Tβ4) is a 43 amino acid peptide that is found in nearly every cell in the body, except for red blood cells2. The peptide is also found in certain bodily fluids including tears, saliva, cerebrospinal fluid, and wound fluids. While it is one of the smaller peptides, it is a powerful and wide-ranging regenerative stimulant.
Tβ4 is a naturally occurring peptide that plays an important role in the repair cascade that is responsible for wound healing. In other words, it is one of the triggers that activate healing around injuries and weakening areas of the body. As soon as the signal reaches important cellular receptors, Tβ4 is triggered and stimulates healing and a slew of compounds that lead to its powerful benefits and healing properties.
Tβ4 was actually one of the first peptides of its kind to be classified and characterized, with testing and research dating as far back as the 1980’s3. The first study to show that Tβ4 promoted tissue repair was a study performed in rats4. While the peptide had previously been found to promote angiogenesis (new blood vessel generation) and was reported to be high in platelets6, this study identified its critical role in the healing process. Since platelets are the first cells to enter a wound, it was clear that Tβ4 had a high potential for clinical use. Over the years, research has gained steam and has begun to prove that Tβ4 is a highly effective healing agent that can benefit a very long list of injuries, degenerative conditions, and diseases in a variety of tissue types.
Benefits of Thymosin Beta-4 Treatment
Tβ4 is a miracle pain management, wound healing, and regenerative therapy that can help with a variety of conditions and injuries that plague both athletes and the everyday person. It has been found to play an important role in the protection, regeneration, and rebuilding of damaged tissues by releasing platelets, triggering stem cell migration, and recruiting numerous other types of important antibody and protein-stimulating cells to the key affected areas.
- Helps maintain flexibility
- Reduces harmful inflammation in joints
- Encourages the growth of new blood vessels
- Improves healthy blood flow
- Increased endurance and strength
What Is BPC-157?
BPC-157, or Pentadecapeptide, is a 15-amino acid peptide that is classified as a “body-protection compound” or BPC. The peptide is a naturally occurring compound that is found in the gastric juices of the stomach, which is what makes it such an interesting and suitable treatment method. BPC-157 is also known as a “stable gastric pentadecapeptide” because it is stable in human gastric juice, can cause healing effects in both the upper and lower GI tract, has an antiulcer effect, and also produces a therapeutic effect on inflammatory bowel disease (IBD)—all again free of any side effects5. BPC-157’s role in the healing process is closely tied to the hormone HGH and its peptide relative Sermorelin, which we will dive into later.
All of these substances have been found to play a role in similar processes such as tissue healing6, bone maintenance, blood vessel/blood pressure maintenance, and overall metabolic improvement. These findings show that BPC-157 is another substance that, if used in combination with a hormonal specialist and healthy lifestyle, can help you to live with less pain and an increased ability to stay strong throughout middle age and later.
Benefits of BPC-157 Treatment
BPC-157 is a reliable treatment option for pain of any kind, and it also has the ability to help manage a variety of different stomach conditions such as pain, tenderness, ulcers, and bloating.5 In addition to being a powerful source of healing, BPC-157 also has the ability to improve recovery from exercise, increase endurance, and overall allow users to smash through their athletic plateaus.
Researchers have conducted numerous studies on BPC-157 that all have demonstrated that its protective effects extend throughout the body in tissues, blood vessels, neural tissue, and more. It has the potential to help athletes recover from injuries faster, treat stomach and bowel conditions more quickly, and also help men and women age 35 and older benefit from enhanced healing capabilities, metabolic efficiency, as well as improved mood, cognition, and memory.
Benefits that BPC-157 include:
- Soft tissue healing
- Pain management
- Post-workout recovery
- Blood pressure rebalancing
- Calcium rebalancing
- Potassium rebalancing
- Tendon and ligament regeneration
- Skin repair
- Nootropic benefits
- Decreased depressive tendencies
- Nerve cell regeneration
- Ulcer relief and gut health improvement
Who Are These Peptides For?
Tβ4 and BPC-157 can be great additions to any kind of active lifestyle. If you are a weekend adventurer, CrossFit athlete, or just like to stay in shape in general – then these peptides can help you recover and perform at your best all year round. The magic of these peptides is their ability to help your body improve its ability to come back stronger after each workout while keeping you performing at your highest potential when you need to.
In addition, these peptides are also great for athletes or even the everyday individual that may be recovering from musculoskeletal injuries. These peptides help to improve the crucial healing process of skeletal muscle while also improving nerve cell regeneration as well. With additional benefits such as improved blood flow and angiogenesis (blood vessel formation), these two peptides are recovery powerhouses that can help you get back to performing at your best.
Tβ4 and BPC-157 – Multifunctional Healing
As we have seen, Tβ4 and BPC-157 both have incredible pain management and regenerative capabilities that can help with a variety of use cases ranging from athletic recovery to post-surgery rehabilitation. These two peptides have some major similarities including the ability to reduce harmful inflammation, improve tissue healing, and also provide improved overall recovery from injury or exercise.
While Tβ4 is more geared towards widespread tissue regeneration and anti-inflammatory properties, BPC-157 is more focused on providing gut-healing properties and nootropic benefits (BPC-157 does also provide muscle regeneration benefits as well, though). Tβ4 is more suited to assist with the creation of new blood vessels and the overall healing and repair processes that occur throughout the body.
In other words, BPC-157 has been found to have a more focused effect on certain chronic conditions while also improving nerve cell regeneration and tendon-ligament healing, while Tβ4 is a powerful agent that boosts the efficacy of the body’s natural tissue healing cascade. Overall, Tβ4 and BPC-157 are both great options for athletes or anyone in general who wants to optimize their body’s healing and regenerative capabilities.
Tβ4 and BPC-157 come in various formulations, depending on the desired effect. Tβ4 is commonly prescribed as a capsule taken daily, where as BPC- 157 comes in capsule, cream, nasal spray, troche and subcutaneous injection formulations. Patients often use one or both peptides when repairing damage to muscles, ligaments and or tendons. Both peptides are popular with weekend warriors or competitive athletes, who require reduced recovery time. Patients with tendon/ligament injuries frequently use BPC-157 to avoid surgical intervention and increase speed of recovery.
- Goldstein, Hannappel, Sosne (2012). Thymosin β4: A Multi-Functional Regenerative Peptide. Basic Properties and Clinical Applications. Expert Opinion on Biological Therapy, 12(1):37-51 https://pubmed.ncbi.nlm.nih.gov/22074294/
- Kleinman, Sosne, (2016). Thymosin β4 Promotes Dermal Healing, Vitamins and Hormones, 102, 251-275
- Low et al., (1981). Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. PNAS February 1, 1981 78 (2) 1162-1166
- Goldstein, Kleinman, Malinda, Mani (1999). Thymosin β4 Accelerates Wound Healing. Journal of Investigative Dermatology, 113, 364-368.
- Gwyer, Wilson, Wragg, (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Current Pharmaceutical Design. 377(2):153-159
- Barisic, Klicek, Horvat, Radic, Sever, Rucman, Turkovic, et. al (2018). BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing, Current Pharmaceutical Design. 24(18):1972-1989. https://pubmed.ncbi.nlm.nih.gov/29998800/
- Chang, Chung-Hsun, et al. “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.” Journal of Applied Physiology 110.3 (2011): 774-780.